The CAVADEX® molecule
CAVADEX® (developed by Cholrem Pty Ltd) is a form of Hydroxypropyl beta cyclodextrin (HPßCD) that is comprised of seven sugar molecules bound together in a ring (cyclic oligosaccharide).
The ring-shaped, three-dimensional structure has a hydrophobic cavity in its center, which is capable of trapping cholesterol and lipids. It has been used extensively as an excipient in the food, deodorant, and drug industry for the past century, and it is generally recognized as safe (GRAS).
As an active ingredient, CAVADEX® entraps and removes intracellular cholesterol and lipids that can cause injury to the kidneys and other organs, including the brain and liver.
Cyclodextrin harmlessly absorbs cholesterol from cells
Related Articles
"Cyclodextrin reprogrammed the cells in plaques, leading to increased transport of the dissolved cholesterol away from the plaques..."
nature.com : Molecule melts away cholesterol."Cyclodextrin dissolves cholesterol crystals and reduces atherosclerotic plaques..."
sciencedaily.com : Drug used for rare disease may be able to treat heart disease."Soaked up cholesterol and removed it..."
sciencedaily.com : New hope for treating atheriosclerosis"have the potential in lowering deaths caused by atherosclerosis..."
ntnu.co : Can a sugar treat atherosclerosis?"can actually solubilize cholesterol and dissolve the plaques..."
huffpost.com : Cholesterol sweet spot.
CAVADEX® removes plaque and cholesterol
plaque reduced in just 4 weeks
A recent study by the University Hospital in Bonn, Germany discovered that cyclodextrin melts away cholesterol crystals (the main cause of arterial plaque that clogs arteries) and reduced existing plaque within just 4 weeks. The cyclodextrin bound to and dissolved the cholesterol crystals from the plaque of mice, leading to transport of the dissolved cholesterol away from the plaques. The same effects were seen in human plaque samples treated with cyclodextrin.
Article : Cyclodextrin promotes atherosclerosis regression via macrophage reprogrammingImprove Liver function
Another study by the University of Texas Southwestern Medical Center, Dallas, Texas, shows the treatment of Npc1-deficient mice slows cholesterol sequestration in major organs and improves liver function. This study shows that cyclodextrin is effective in mobilizing entrapped cholesterol in late stage NPC disease leading to improved liver function.
Article : Systemic administration of 2-hydroxypropyl-B-cyclodextrin to symptomatic Npc1-deficient mice slows cholesterol sequestration in the major organs and improves liver function.Cyclodextrin Publications
About Cyclodextrins
Molecular mechanism of cyclodextrin mediated cholesterol extraction
Rationale for Therapeutic Use of Lipid Transport Mediators in Renal Disease
Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury.
Systemic and renal lipids in kidney disease development and progression
Lipid biology of the podocyte--new perspectives offer new opportunities.
Renal lipid metabolism and lipotoxicity.
Cyclodextrins and Non-renal Diseases
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming.
Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease.
Cyclodextrins and Renal Disease
Cyclodextrin Protects Podocytes in Focal Segmental Glomerulosclerosis (FSGS)
Cyclodextrin improves renal function in experimental alport syndrome.